Control of Protein Particle Formation During Ultrafiltration/Diafiltration Through Interfacial Protection
نویسندگان
چکیده
منابع مشابه
Control of Protein Particle Formation During Ultrafiltration/Diafiltration Through Interfacial Protection
This study investigates the mechanism of protein particle formation during ultrafiltration/diafiltration (UF/DF), finding that agitation drives particle formation by promoting protein-interface adsorption and desorption. Low conductivity and the presence of surfactant reduced the level of particle formation in small-scale stirring studies, and the same trends were observed in pumping and UF/DF....
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2014
ISSN: 0022-3549
DOI: 10.1002/jps.23861